Non Small Cell Lung Cancer - 856 Words

Non-small cell lung cancer (NSCLC) represents 85% of lung cancer case1,2. Due to metastasis and other individual conditions, only 30% of the patients are able to go for a surgery, the best regarded treatment method2. Others predominately use tradition chemo- and radio-based therapeutic methods, which held poor treatment outcome with only 15% of the patient lives longer than 5 years1. However, since the establishment of RNAi therapy in 1998, the efficacy of RNAi on tumour activity related genes was intensively studied and some research trials has shown potential effects in treating NSCLC by this method1-3. RNAi is defined as a mechanism of gene-silencing produced by small RNA fragments (siRNA/miRNA/shRNA) and it also can be described as posttranscriptional gene silencing3. These small RNAs have the ability to selectively bind and cleave cellular mRNAs and prevent their further expression3. This function holds great significance in cancer treatment and cell self-repairing1,3. The mechanism of RNAi therapy consists of multiple steps. Briefly, a double-strand small RNA fragment (~20bp) firstly incorporates into a multiprotein complex, RNA-Induced Silencing Complex (RISC), and their double strands starts unwinding after being activated. The single-stranded small RNAs product then guided activated RISC to identify mRNAs that are complementary to this single-stranded small RNA3,4. Once identified, this mRNA is cleaved by endoribonucleases and then degraded by exoribonucleases inShow MoreRelatedNon Small Cell Lung Cancer1016 Words   |  5 PagesNon-Small cell lung cancer is one of two major cancers that affect smokers and nonsmokers. About 85% of lung cancers are non-small cancers, and at least 80% of that comes from smoking (American Cancer Society). In the United States, lung cancer is the second cancer most frequently diagnosed in both men and women and remains the major cause of cancer-related death.(Jan A. Burger, 2012). It mostly affects group ages from little as 6 to old as 60+. The factors that lead people to get this cancer ofRead MoreEssay On Non Small Cell Lung Cancer1195 Words   |  5 PagesTargeted therapy for non-small cell lung cancer Abstract In the past years, there has been a major paradigm shift in the management of non-small cell lung cancer also known as (NSCLC). NSCLC should now be further sub-classified by histology and driver mutation if one is known or present. Translational research results now allow such mutations to be inhibited by either receptor monoclonal antibodies (mAb) or small molecule tyrosine kinase inhibitors (TKI). Whilst empirical chemotherapy with a platinum-doubletRead MoreTreatment Of Metastatic Squamous Non Small Cell Lung Cancer1744 Words   |  7 Pages(nivolumab) Opdivo (nivolumab); Bristol-Myers Squibb; For the treatment of metastatic squamous non-small cell lung cancer, Approved March 2015 WEDNESDAY, March 4, 2015 (HealthDay News) -- U.S. Food and Drug Administration approval of Opdivo (nivolumab) has been expanded to include advanced non-small cell lung cancer (NSCLC), the agency said Wednesday in a news release. Lung cancer is the leading cause of cancer death in the United States, having been diagnosed more than 224,000 times and causing moreRead MoreMost Common Type Of Cancer Worldwide Essay1550 Words   |  7 PagesCancer is the leading cause of death in the world. An astounding average of 1.6 million deaths occur due to lung cancer every year, making it the most common type of cancer worldwide (1). Lung cancer is broadly classified into two types: small cell and non-small cell lung carcinoma (NSCLC). 85% of all lung cancer cases are NSCLC. NSCLC has several different histologic subtypes, some of which are: squamous cell carcinoma, large cell carcinoma, and adenocarcinoma. Of the three, adenocarcinoma accountsRead MoreDr. Antonia And Colleagues Report On The Combination Of Durvalumab And Tremelimumab750 Words   |  3 PagesIn this issue of Lancet Oncology, Dr. Antonia and colleagues report on the combination of durvalumab and tremelimumab in patients with non-small cell lung cancer (NS CLC).1 After the recent approvals of nivolumab and pembrolizumab in NSCLC,2, 3, 4 there is a near frenzy of attempts to combine agents with inhibitors of the PD-1 immune checkpoint. Some efforts are based on only the shakiest of scientific evidence. However, the combination of durvalumab, a PD-L1 inhibitor, and tremelimumab, a CTLA-4Read Morelung cancer927 Words   |  4 Pagesï » ¿ Lung Cancer By Brayan Almora and Hector Aparicio Pedroza Ms. Powell, 7th Language Arts Problem – Solution Paper May 15, 2014 Lung Cancer Causes and Treatments Lung cancer is defined as abnormal cell tissue that forms in tissues of the lungs. It is estimated that there are 224,210 new cases every year, while the estimated deaths are numbered at 159,260 per year . There are several options of treatment and are as follows: Surgery, Chemotherapy, Radiation TherapyRead MoreLung Cancer Essay1665 Words   |  7 PagesIn 2013 there were an estimated 159,480 deaths due to lung cancer in the United States alone (Lung Cancer). Lung cancer is an unrelenting disease that is caused by many environmental factors and personal habits. It begins as mutations within a cell’s DNA and eventually progresses to a tumor which can then spread to various other parts of the body. There is no cure for lung cancer presently, however there are numerous treatments available to patients in hopes of eradicating or at least controllingRead MoreLung Cancer1304 Words   |  6 Pages LUNG CANCER Mohamed Almasmary Bio240 Anatomy Physiology 1 4/13/14 Lung cancer is a cancer (malignancy) that originates in the tissues of the lungs or the cells lining the airways. Lung cancer originates when normal lung cells become cancer cells, usually after a series of mutations, and begin to divide out of control. Lung Cancer is a disease which consists of uncontrolled cell growth in lung tissues. Lung cancer consists of two types, Non-small cell lung cancer, and small cell lung cancerRead MoreLung Cancer : The Most Common Cause Of Cancer1309 Words   |  6 PagesLung Cancer is by far the most common cause of cancer related death in the world. Every year more than 200,00 Americans are diagnosed with lung cancer and over 100,000 Americans die from lung cancer. Lung Cancer is partly preventable with smoking cessation and it is slowly decreasing in the developed countries because of the many campaigns against tobacco addiction developed in the last decades but this is not the case in developing countries. In addition, we are observing a growing amount ofRead More Lung Cancer Essay1667 Words   |  7 Pagesof lung cancer, non-small cell lung cancer and small cell lung cancer. It is all depending on the size of what the cells look like under a microscope. Both of these types of lung cancer can grow differently which leads to them both being treated differently. Non-small cell lung cancer is the more common of the two and it usually grows fairly slow. There are three main types of non-small cell lung cancer and they are squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Small cell cancer